Reduction of Liver Glutathione Peroxidase Activity and Deficiency of Serum Selenium in Patients with Hepatocellular Carcinoma-Reference-Cited by-同舟云学术

Reduction of Liver Glutathione Peroxidase Activity and Deficiency of Serum Selenium in Patients with Hepatocellular Carcinoma

Published:1986-12 Issue:6 Volume:72 Page:617-619
ISSN:0300-8916
Container-title:Tumori Journal
language:en
Short-container-title:Tumori

Author:

Corrocher Roberto¹,Casaril Massimo¹,Bellisola Giuseppe¹,Gabrielli Giovanbattista¹,Hulpe Minerva²,Garofoli Enrico²,Nicoli Nicola³

Affiliation:

1. Institute of Medical Pathology, University of Verona

2. Institute of Clinical Chemistry, University of Verona

3. Institute of Clinical Surgery, University of Verona

Abstract

Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with hystologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p < 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/030089168607200613

Reference12 articles.

1. Dietary Carcinogens and Anticarcinogens

2. Selenium-dependent and non-selenium-dependent glutathione peroxidases in human tissue extracts

3. Decreased activity of liver glutathione peroxidase in human hepatocellular carcinoma

4. Prooxidant States and Tumor Promotion

5. Severe impairment of antioxidant system in human hepatoma

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