Suspected Ofloxacin-Induced Seizures in an Elderly Patient

Abstract

Objective: To report a case of probable ofloxacin-induced seizures. Case Summary: A 74-year-old white man received a single intravenous dose of ofloxacin administered over a 60-minute period. Approximately 4 hours later, he developed seizure-like tremors in all extremities, fecal incontinence, and shortness of breath with harsh, labored breathing. Ofloxacin was discontinued, and the seizure-like tremors subsided within 4 hours of onset. Discussion: The time course of events suggested that ofloxacin was the cause of a suspected seizure in this patient. Other causes of seizure were ruled out. Seizures have been reported in less than 1% of patients receiving ofloxacin. Conclusions: Ofloxacin can cause seizures, and healthcare providers should be aware of the potential for this adverse effect.