Cardiovascular Risks of Fluphenazine in a Patient With Schizophrenia

Author:

Burton Samantha1,Prokop Matthew1,Kaakeh Yaman12

Affiliation:

1. Purdue University College of Pharmacy, West Lafayette, IN, USA

2. Indiana University School of Medicine, Indianapolis, IN, USA

Abstract

Objective: Patients with psychiatric illnesses are at an increased risk for heart disease, and many antipsychotic medications elicit adverse effects on the heart. This report summarizes conduction abnormalities manifested as chest pain when a patient is treated with fluphenazine decanoate. Case Summary: A 61-year-old male with a history of schizophrenia, coronary artery disease, and atrial fibrillation presented complaining of chest pain and shortness of breath with moderate T-wave abnormality detected on electrocardiogram. The patient recently initiated fluphenazine decanoate intramuscular injection while continuing oral fluphenazine as directed. Discussion: Utilizing the Naranjo algorithm, the cardiac conduction abnormality was determined to be a possible adverse event associated with fluphenazine use. This was based on recent initiation and increasing dose of fluphenazine and documented association of antipsychotics and risk of Torsades de Pointes. Conclusions: While it is known that fluphenazine decanoate can cause extrapyramidal adverse effects, this case demonstrates that it may also play a role in causing or exacerbating cardiovascular adverse events. Continued cardiovascular monitoring after starting fluphenazine decanoate is warranted.

Publisher

SAGE Publications

Subject

Pharmaceutical Science

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Fluphenazine decanoate‐induced bradycardia: A case report;Neuropsychopharmacology Reports;2022-04-03

2. Fluphenazine/haloperidol/ziprasidone;Reactions Weekly;2018-08

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