Gepirone: A New Extended-Release Oral Selective Serotonin Receptor Agonist for Major Depressive Disorder

Author:

Phillips Bradley1ORCID,O’Connor Colin1,St. Onge Erin1ORCID

Affiliation:

1. Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Orlando, FL, USA

Abstract

Objective: To evaluate the safety, efficacy, and tolerability of gepirone (Exxua) in the treatment of adult patients with major depressive disorder. Data Sources: A literature search was performed through PubMed, Embase, and PsycINFO using the following terms: Exxua, gepirone, depression, major depressive disorder, anxiety, and anxiety disorders. Study Selection and Data Extraction: Articles that were selected included English-language dominant studies, or studies that could be translated into English by the authors, with terms associated with the safety, efficacy, and/or tolerability of gepirone. Data Synthesis: Gepirone exhibits its antidepressant activity through agonism of 5HT1A serotonin receptors. Phase 3 clinical trials showed that gepirone at a dose of 20 to 80 mg was proven to be effective in the treatment of major depressive disorder in adult patients. Common adverse effects reported in clinical trials included dizziness, nausea, headache, fatigue, and insomnia. Conclusion: This review evaluates the pharmacokinetic, pharmacologic, efficacy, and safety profile of gepirone and includes a discussion on its place in therapy for the treatment of major depressive disorder. Most clinical guidelines recommend second-generation antidepressants consisting of selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors as first-line therapy options. Gepirone is expected to receive greater clinical relevance and recommendations when compared to other azapirone medications (buspirone) within practice guidelines. Gepirone could be considered as either an alternative option for patients failing first-line therapies or for initial use to avoid unwanted side effects of other therapy options in the treatment of adult patients with major depressive disorder.

Publisher

SAGE Publications

Reference24 articles.

1. Depressive disorder (depression). World Health Organization. Published March 31, 2023. Accessed February 7, 2024. https://www.who.int/newsroom/fact-sheets/detail/depression.

2. Major depression. National institute of mental health. Published July 2023. Accessed February 7, 2024. https://www.nimh.nih.gov/health/statistics/major-depression.

3. Depression Is the Leading Cause of Disability Around the World

4. The Economic Burden of Adults with Major Depressive Disorder in the United States (2010 and 2018)

5. Undertreatment of people with major depressive disorder in 21 countries

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