Erythromycin-Induced Ototoxicity: Case Report

Author:

Fayed Desouky F.,Dahmash Nabil S.

Abstract

Objective: To report a case of erythromycin-induced ototoxicity and to discuss the occurrence of this event. Case Summary: A 26-year-old woman was admitted to the medical intensive care unit with a two-day history of progressive shortness of breath, high-grade fever, cough, and pleuritic chest pain. Arterial blood gases on room air showed severe hypoxemia, and a chest X-ray revealed right lower-lobe infiltrates. Provisional diagnosis was atypical pneumonia, for which erythromycin lactobionate 1 g q6h iv was administered. All other chronic medications were maintained at the same dosage and frequency. All laboratory work remained stable. After 36 hours, the patient developed sensorineural hearing loss. Erythromycin was stopped immediately. After 24 hours, there was subjective improvement of hearing, with complete return to pretreatment levels in 72 hours. Discussion: A review of the literature showed only 40 reported cases of reversible ototoxicity, mainly with high dosages of erythromycin (4 g/d). Conclusions: High-dose erythromycin therapy can cause reversible sensorineural hearing impairment. Treatment with erythromycin 4 g/d should be reserved for immunosuppressed patients with Legionnaires' disease and patients with Legionella endocarditis. Patients should have a baseline audiogram and regular monitoring for subjective evidence of sensorineural hearing loss, and the drug should be discontinued if ototoxicity is suspected.

Publisher

SAGE Publications

Subject

Pharmaceutical Science

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3