Efficacy and Toxicity of Amphotericin B Liposomal and Lipid Formulations

Abstract

Objective: To review the efficacy and toxicity of amphotericin B liposomal and various lipid formulations with conventional amphotericin B desoxycholate. Data Sources: Pertinent literature was identified via a MEDLINE search. Study Selection: English-language clinical trials. Conclusions: The incorporation of amphotericin B into liposomes or lipid formulations appears to be a novel method of administering amphotericin B for the treatment of serious systemic fungal infections for patients who have either failed therapy with, or are intolerant to, conventional amphotericin B desoxycholate.