Quantitative Correlation with Carcinogenic Potency of Different Short Term Tests

Abstract

The following short term parameters evaluating essentially genotoxic effects were considered: liver DNA alkaline fragmentation (DFI), morphological transformation in hamster embryo cells (TPI), and mutagenicity in the Ames’ test (MPI). The internal consistency of the carcinogenicity data (OPI) was rather high (r = 0.8). The correlation with OPI of DFI and MPI was statistically significant but rather modest, about 0.4-0.5. The best correlation between OPI and TPI was 0.65. This level of correlation was observed only when some kind of dose-response relationship for transformation could be established. When comparisons were attempted for exactly the same 27 compounds for all three tests, a general decrease in predictability was observed. This could be mainly due to problems of representation of the ideal population of chemicals using small samples. The more general problem of the quantitative approach to the predictability of short term tests was also discussed.