An Autoradiographic Study of the Renewal of Mouse Bronchiolar Epithelium Following Bromobenzene Exposure-Reference-Cited by-同舟云学术

An Autoradiographic Study of the Renewal of Mouse Bronchiolar Epithelium Following Bromobenzene Exposure

Published:1993-11 Issue:6 Volume:21 Page:547-553
ISSN:0192-6233
Container-title:Toxicologic Pathology
language:en
Short-container-title:Toxicol Pathol

Author:

Ogawa Takehiko¹,Tsubakihara Motofumi¹,Ichikawa Misao²,Kanisawa Masayoshi¹

Affiliation:

1. Department of Pathology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, 236, Japan

2. Department of Anatomy, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, 236, Japan

Abstract

This study discusses mice bronchiolar epithelium following bromobenzene (BrBZ) exposure. Our study shows 3 cell types following BrBZ exposure: Clara cells, ciliated cells, and newly discovered BrBZ-resistant nonciliated cells. Through electron microscopic autoradiography, we were able to show the proliferative ability of BrBZ-resistant nonciliated cells. This finding suggests that BrBZ-resistant nonciliated cells may function as progenitor cells. In addition to discovering this new cell type, our results also demonstrate and confirm the proliferative ability of modified Clara cells.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/019262339302100605

Reference22 articles.

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