Proceedings of the 2017 National Toxicology Program Satellite Symposium

Author:

Elmore Susan A.1,Aeffner Famke2,Bangari Dinesh S.3,Crabbs Torrie A.4,Fossey Stacey5,Gad Shayne C.6,Haschek Wanda M.7,Hoane Jessica S.8,Janardhan Kyathanahalli9,Kovi Ramesh C.4,Pearse Gail10,Wancket Lyn M.11,Quist Erin M.4

Affiliation:

1. Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

2. Amgen, Inc., South San Francisco, California, USA

3. Sanofi Genzyme, Framingham, Massachusetts, USA

4. Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA

5. AbbVie Bioresearch Center, Worcester, Massachusetts, USA

6. Gad Consulting Services, Raleigh, North Carolina, USA

7. Department of Pathobiology, University of Illinois, Urbana, Illinois, USA

8. Charles River Laboratories, Inc., Durham, North Carolina, USA

9. Integrated Laboratory Systems, Inc., Research Triangle Park, North Carolina, USA

10. GlaxoSmithKline, Ware, Hertfordshire, United Kingdom

11. NAMSA, Northwood, Ohio, USA

Abstract

The 2017 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Montreal, Quebec, Canada at the Society of Toxicologic Pathology’s 36th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were used by the audience for voting and discussion. Various lesions and other topics covered during the symposium included renal papillary degeneration in perinatally exposed animals, an atriocaval mesothelioma, an unusual presentation of an alveolar–bronchiolar carcinoma, a paraganglioma of the organ of Zuckerkandl (also called an extra-adrenal pheochromocytoma), the use of human muscle samples to illustrate the challenges of manual scoring of fluorescent staining, intertubular spermatocytic seminomas, medical device pathology assessment and discussion of the approval process, collagen-induced arthritis, incisor denticles, ameloblast degeneration and poorly mineralized enamel matrix, connective tissue paragangliomas, microcystin-LR toxicity, perivascular mast cells in the forebrain thalamus unrelated to treatment, and 2 cases that provided a review of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) bone nomenclature and recommended application of the terminology in routine nonclinical toxicity studies.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

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