Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems: New and Revised INHAND Terms

Author:

Bradley Alys E.1ORCID,Bolon Brad2ORCID,Butt Mark T.3ORCID,Cramer Sarah D.3,Czasch Stephanie4,Garman Robert H.5,George Catherine6,Gröters Sibylle7,Kaufmann Wolfgang8,Kovi Ramesh C.910,Krinke Georg11,Little Peter B.12,Narama Isao13,Rao Deepa B.3,Sharma Alok K.14ORCID,Shibutani Makoto15,Sills Robert10

Affiliation:

1. Charles River Laboratories Edinburgh Ltd., Tranent, United Kingdom

2. GEMpath, Inc., Longmont, CO, USA

3. Tox Path Specialists, LLC, Frederick, MD, USA

4. Merck Healthcare KGaA, Darmstadt, Germany

5. Consultants in Veterinary Pathology, Inc., Murrysville, PA, USA

6. Ipsen Innovation, Les Ulis, France

7. BASF SE, Ludwigshafen, Germany

8. Independent Consultant, Bad Duerkheim, Germany

9. Experimental Pathology Laboratories (EPL), Inc., Research Triangle Park, NC, USA

10. National Toxicology Program (NTP), US National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA

11. AnaPath GmbH, Oberbuchsiten, Switzerland

12. Experimental Pathology Laboratories (EPL), Inc., Durham, NC, USA

13. BioSafety Research Center, Inc. (BSRC), Iwata, Japan

14. Covance Laboratories, Inc., Madison, WI, USA

15. Tokyo University of Agriculture and Technology, Laboratory of Veterinary Pathology, Tokyo, Japan

Abstract

Harmonization of diagnostic terminology used during the histopathologic analysis of rodent tissue sections from nonclinical toxicity studies will improve the consistency of data sets produced by laboratories located around the world. The INHAND Project ( International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a cooperative enterprise of 4 major societies of toxicologic pathology to develop a globally accepted standard vocabulary for proliferative and nonproliferative lesions in rodents. A prior manuscript ( Toxicol Pathol 2012;40[4 Suppl]:87S-157S) defined multiple diagnostic terms for toxicant-induced lesions, common spontaneous and age-related changes, and principal confounding artifacts in the rat and mouse central nervous system (CNS) and peripheral nervous system (PNS). The current article defines 9 new diagnostic terms and updates 2 previous terms for findings in the rodent CNS and PNS, the need for which has become evident in the years since the publication of the initial INHAND nomenclature for findings in rodent neural tissues. The nomenclature presented in this document is also available electronically on the Internet at the goRENI website ( http://www.goreni.org/ ).

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

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