International Harmonization of Toxicologic Pathology Nomenclature-Reference-Cited by-同舟云学术

International Harmonization of Toxicologic Pathology Nomenclature

Published:2012-05-25 Issue:4_suppl Volume:40 Page:7S-13S
ISSN:0192-6233
Container-title:Toxicologic Pathology
language:en
Short-container-title:Toxicol Pathol

Author:

Mann Peter C.¹,Vahle John²,Keenan Charlotte M.³,Baker Julia F.⁴,Bradley Alys E.⁵,Goodman Dawn G.⁶,Harada Takanori⁷,Herbert Ronald⁸,Kaufmann Wolfgang⁹,Kellner Rupert¹⁰,Nolte Thomas¹¹,Rittinghausen Susanne¹⁰,Tanaka Takuji¹²

Affiliation:

1. EPL Northwest, Seattle, Washington, USA

2. Eli Lilly & Company, Indianapolis, Indiana, USA

3. C. M. Keenan ToxPath Consulting, Doylestown, Pennsylvania, USA

4. Charles River Pathology Associates, Frederick, Maryland, USA

5. Charles River Laboratories, Tranent, Scotland, UK

6. Private Consultant, Potomac, Maryland, USA

7. The Institute of Environmental Toxicology, Ibaraki, Japan

8. NIEHS, Research Triangle Park, NC, USA

9. Merck Serono R&D, Darmstadt, Germany

10. Fraunhofer ITEM, Hannover, Germany

11. Boehringer Ingelheim Pharma, Biberach an der Riss, Germany

12. Kanazawa Medical University, Ishikawa, Japan

Abstract

The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0192623312438738

Reference15 articles.

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3. Use and Misuse of Statistics in the Design and Interpretation of Studies

4. Greaves P. (2007). Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation, 3rd ed. p. 7. Elsiever, Amsterdam, The Netherlands.

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