Sulfation of N-hydroxy-2-acetylaminofluorene in Normal and Nodular Liver from Male Wistar Rats-Reference-Cited by-同舟云学术

Sulfation of N-hydroxy-2-acetylaminofluorene in Normal and Nodular Liver from Male Wistar Rats

Published:1987-01 Issue:1 Volume:15 Page:103-105
ISSN:0192-6233
Container-title:Toxicologic Pathology
language:en
Short-container-title:Toxicol Pathol

Author:

Blanck Agneta¹,Wicksell Lottie¹,Eriksson Lennart C.²

Affiliation:

1. Department of Medical Nutrition

2. Department of Pathology, Karolinska Institute, F 69, Huddinge University Hospital, 141 86 Huddinge, Sweden

Abstract

Hepatocyte nodules produced by cyclic feeding of the rat liver carcinogen 2-acetylaminofluorene to male rats have been shown to exhibit specific metabolic characteristics. None of the characteristics of nodular tissue so far investigated has provided any explanation why initiated cells, such as in the “resistant hepatocyte model,” were resistant to the mitoinhibitory effects of 2-acetylaminofluorene. In the present study, hepatocyte nodules are produced by cyclic feeding of 0.05% 2-AAF in the diet to male Wistar rats. N-hydroxy-2-acetylaminofluorene sulfotransferase levels were determined in the postmicrosomal supernatant prepared from nodules and from control rat liver. The average sulfotransferase activities were 0.29 and 4.75 nmol p-nitrophenol formed/min × mg protein, respectively. We suggest that the low sulfotransferase activity in preparations from nodular tissue might be an important part of the explanation for the resistance of focal and nodular tissue to the mitoinhibitory effects of 2-acetylaminofluorene.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/019262338701500115

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2. On mechanisms of sex differences in chemical carcinogenesis: effects of implantation of ectopic pituitary grafts on the early stages of liver carcinogenesis in the rat

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