Clinical Pathology Testing Recommendations for Nonclinical Toxicity and Safety Studies

Author:

Weingand Kurt1,Bloom John,Carakostas Michael,Hall Robert,Helfrich Maria,Latimer Kenneth,Levine Barry,Neptun Douglas,Rebar Alan,Stitzel Katherine,Troup Catherine

Affiliation:

1. The Procter & Gamble Co., Miami Valley Laboratories, P.O. Box 398707, Cincinnati, Ohio 45239

Abstract

Clinical pathology testing in nonclinical toxicity and safety studies is an important part of safety assessment. In recent years, clinical laboratory testing has rapidly expanded and improved. Some government regulatory agencies provide guidelines for clinical pathology testing in nonclinical toxicity and safety studies. To improve these testing guidelines and the resultant safety assessments, the American Association for Clinical Chemistry's Division of Animal Clinical Chemistry and the American Society for Veterinary Clinical Pathology formed a joint committee to provide expert recommendations for clinical pathology testing of laboratory species involved in subchronic and chronic nonclinical toxicity and safety studies. These recommendations include technical recommendations on blood collection techniques and hematology, serum chemistry, and urinalysis tests.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Reference32 articles.

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