Commentary: Update on Animal Models for NTP Studies-Reference-Cited by-同舟云学术

Commentary: Update on Animal Models for NTP Studies

Published:2009-12-17 Issue:1 Volume:38 Page:180-181
ISSN:0192-6233
Container-title:Toxicologic Pathology
language:en
Short-container-title:Toxicol Pathol

Author:

King-Herbert Angela P.¹,Sills Robert C.²,Bucher John R.³

Affiliation:

1. Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC, USA, Kingher1@niehs.nih.gov

2. Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC, USA

3. National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP), Research Triangle Park, NC, USA

Abstract

Based on recommendations of participants at the National Toxicology Program (NTP) workshop ‘‘Animal Models for the NTP Cancer Bioassay: Strains and Stocks—Should We Switch?’’ some modifications to the NTP rodent cancer bioassay were made. The B6C3F1 remains the mouse model used in the cancer bioassay. The use of multiple strains of mice will be explored through a new branch within the NTP, the Host Susceptibility Branch. Several rat models were evaluated; the Harlan Sprague Dawley rat is currently being used in the NTP studies.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/0192623309356450

Reference4 articles.

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3. NTP Workshop: Animal Models for the NTP Rodent Cancer Bioassay: Stocks and Strains—Should We Switch?

4. Point Mutation in Intron Sequence Causes Altered Carboxyl-Terminal Structure in the Aryl Hydrocarbon Receptor of the Most 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Resistant Rat Strain

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