The Placenta in Toxicology. Part III

Author:

Cline J. Mark1,Dixon Darlene2,Ernerudh Jan3,Faas Marijke M.4,Göhner Claudia5,Häger Jan-Dirk6,Markert Udo R.5,Pfarrer Christiane6,Svensson-Arvelund Judit3,Buse Eberhard7

Affiliation:

1. Department of Pathology/Section on Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

2. National Institute of Environmental Health Sciences, National Toxicology Program (NTP), Molecular Pathogenesis, NTP Laboratory, Research Triangle Park, North Carolina, USA

3. Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

4. Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

5. Placenta-Labor, Department of Obstetrics. University Hospital Jena, Jena, Germany

6. Department of Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany

7. Covance Laboratories GmbH, Muenster, Germany

Abstract

This short review is derived from the peer-reviewed literature and the experience and case materials of the authors. Brief illustrated summaries are presented on the gross and histologic normal anatomy of rodent and macaque placentas, including typical organ weights, with comments on differences from the human placenta. Common incidental findings, background lesions, and induced toxic lesions are addressed, and a recommended strategy for pathologic evaluation of placentas is provided.

Publisher

SAGE Publications

Subject

Cell Biology,Toxicology,Molecular Biology,Pathology and Forensic Medicine

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