Acute Treatment of Bipolar Disorder with Adjunctive Risperidone in Outpatients-Reference-Cited by-同舟云学术

Acute Treatment of Bipolar Disorder with Adjunctive Risperidone in Outpatients

Published:1997-03 Issue:2 Volume:42 Page:196-199
ISSN:0706-7437
Container-title:The Canadian Journal of Psychiatry
language:en
Short-container-title:Can J Psychiatry

Author:

Ghaemi S Nassir¹,Sachs Gary S²³,Baldassano Claudia F³⁴,Truman Christine J³⁵

Affiliation:

1. Senior Investigator, Center on Neuroscience, Medical Progress and Society, George Washington University, Washington, District of Columbia

2. Director, Harvard Bipolar Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts

3. Consolidated Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts

4. Research Fellow, Harvard Bipolar Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts

5. Research Coordinator, Harvard Bipolar Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts

Abstract

Objective: To test the hypothesis that, although typical neuroleptics are commonly used in the treatment of bipolar disorder, newer atypical antipsychotic agents, like risperidone, may be more effective and better-tolerated. Method: The effectiveness of risperidone was evaluated in 14 outpatients with bipolar disorder, type I, who received risperidone for 6.4 ± 2.7 weeks at 2.75 ± 1.8 mg/day. Results: Nine (64%) patients were much improved based on Clinical Global Impression (CGI) scores, and mean Global Assessment of Functioning (GAF) scores improved from 48.2 ± 4.9 to 58.8 ± 7.3 (t = 4.49, P = 0.0006, paired t test). Treatment was well tolerated, and no patient experienced worsening of mood symptoms while receiving risperidone. Conclusion: This open series suggests risperidone is beneficial in the treatment of outpatients with bipolar disorder.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

Link

http://journals.sagepub.com/doi/pdf/10.1177/070674379704200211

Reference15 articles.

1. Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic

2. Prospective Study of Tardive Dyskinesia Incidence in the Elderly

3. Clozapine in the treatment of dysphoric mania

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