Possible Interaction between Fluoxetine and Pimozide Causing Sinus Bradycardia-Reference-Cited by-同舟云学术

Possible Interaction between Fluoxetine and Pimozide Causing Sinus Bradycardia

Published:1993-02 Issue:1 Volume:38 Page:62-63
ISSN:0706-7437
Container-title:The Canadian Journal of Psychiatry
language:en
Short-container-title:Can J Psychiatry

Author:

Ahmed Iqbal¹²,Dagincourt Paul G.³,Miller Lawrence G.⁴,Shader Richard I.⁵

Affiliation:

1. Department of Psychiatry, John A. Burns School of Medicine, University of Hawaii, Special Services, Hawaii State Hospital, Kaneohe, Hawaii

2. New England Medical Center, Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts.

3. Triple Board Program in Psychiatry, Child Psychiatry and Pediatrics, Tufts New England Medical Center, Boston, Massachusetts.

4. Tufts University School of Medicine; Associate Director, Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts.

5. Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Division of Clinical Pharmacology, New England Medical Center, Boston, Massachusetts.

Abstract

Fluoxetine has been reported to have interactions with antipsychotics and other antidepressants with symptoms of toxicity of these drugs. We report a case of a possible interaction with pimozide which led to a potentially life threatening bradycardia. Careful monitoring should be done when these two drugs are prescribed at the same time, especially in the elderly and inpatients with cardiac disease.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

Link

http://journals.sagepub.com/doi/pdf/10.1177/070674379303800116

Reference8 articles.

1. Fluoxetine Drug-Drug Interactions

2. Activation of dopaminergic receptors within the caudate-putamen complex facilitates reflex bradycardia in the rat.

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