Altered Amitriptyline Kinetics in a Depressed Patient with Porto-Caval Anastomosis-Reference-Cited by-同舟云学术

Altered Amitriptyline Kinetics in a Depressed Patient with Porto-Caval Anastomosis

Published:1985-03 Issue:2 Volume:30 Page:111-113
ISSN:0706-7437
Container-title:The Canadian Journal of Psychiatry
language:en
Short-container-title:Can J Psychiatry

Author:

Hrdina P.D.¹,Lapierre Y.D.²,Koranyi E.K.³

Affiliation:

1. Department of Pharmacology, University of Ottawa, Ottawa, Ontario.

2. Psychiatry and Pharmacology, University of Ottawa, Ottawa, Ontario; Director of Research, Royal Ottawa Hospital, Ottawa, Ontario.

3. University of Ottawa; Director Education, Royal Ottawa Hospital, Ottawa, Ontario.

Abstract

A case of altered kinetics of amitriptyline in a patient with porto-caval anastomosis and liver cirrhosis who showed an unusually strong sedative response to the drug, is presented. Therapy with tricyclic antidepressants should be initiated with lower doses and adjusted by plasma level monitoring inpatients with liver by-pass.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

Link

http://journals.sagepub.com/doi/pdf/10.1177/070674378503000205

Reference11 articles.

1. Tricyclic Antidepressants

2. PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

3. Clinical response, plasma levels and pharmacokinetics of desiramine in depressed in-patients

4. Pharmacokinetics of psychotropic drugs: What can it tell us?

5. Contribution to the Pharmacokinetics of Amitriptyline

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