Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function-Reference-Cited by-同舟云学术

Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Published:2023-01-13 Issue:5 Volume:68 Page:347-358
ISSN:0706-7437
Container-title:The Canadian Journal of Psychiatry
language:en
Short-container-title:Can J Psychiatry

Author:

Kapustin Daniel¹²^ORCID,Zarei Shadi¹²,Wang Wei²^ORCID,Binns Malcolm A.³⁴,McLaughlin Paula M.⁵,Abrahao Agessandro⁶⁷⁸,Black Sandra E.⁶⁷⁸⁹,Borrie Michael¹⁰,Breen David¹¹,Casaubon Leanna⁶,Dowlatshahi Dar¹²,Finger Elizabeth¹⁰,Fischer Corinne E¹¹³,Frank Andrew¹⁴¹⁵,Freedman Morris⁴⁸,Grimes David¹²,Hassan Ayman¹⁶,Jog Mandar¹⁰,Kwan Donna¹⁷,Lang Anthony⁶⁸¹⁸,Levine Brian⁶,Mandzia Jennifer¹⁰,Marras Connie⁶⁸¹⁸,Masellis Mario⁶⁷⁸,Orange Joseph B.¹⁹,Pasternak Stephen¹⁰²⁰,Peltsch Alicia¹⁷,Pollock Bruce G.¹²,Rajji Tarek K.¹²²¹,Roberts Angela²²²³,Sahlas Demetrios²⁴,Saposnik Gustavo⁶,Seitz Dallas²⁵,Shoesmith Christen²⁶,Southwell Alisia²⁷,Steeves Thomas D.L.⁶⁸¹⁴,Sunderland Kelly⁴,Swartz Richard H⁶⁸²⁷,Tan Brian⁴,Tang-Wai David F.⁶⁸²⁸²⁹,Tartaglia Maria Carmela⁶⁸³⁰,Troyer Angela⁶³¹,Turnbull John²⁴,Zinman Lorne⁶⁷⁸,Kumar Sanjeev¹²,

Affiliation:

1. Department of Psychiatry, University of Toronto, Toronto, ON, Canada

2. Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada

3. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada

4. Rotman Research Institute at Baycrest Health Sciences, Toronto, ON, Canada

5. Nova Scotia Health, Halifax, Nova Scotia, Canada

6. Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada

7. Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

8. Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada

9. LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada

10. University of Western Ontario, London, ON, Canada

11. Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

12. Department of Medicine (Neurology), University of Ottawa Brain and Mind Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada

13. Keenan Research Centre for Biomedical Science, St. Michaels Hospital, Toronto, Ontario, Canada

14. University of Ottawa, Ottawa, ON, Canada

15. Bruyere Research Institute, Ottawa, ON, Canada

16. Thunder Bay Regional Research Institute, Northern Ontario School of Medicine, ON, Canada

17. Queen's University, Kingston, ON, Canada

18. Edmond J. Safra Program in Parkinson's Disesase and the Morton and Gloria Shulman Movement Disorders Centre, University Health Network, Toronto, ON, Canada

19. Canadian Centre for Activity and Aging, Western University, ON, Canada

20. Robarts Research Institute and the Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada

21. Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada

22. School of Communication, Northwestern University, Evanston, Illinois, USA

23. School of Communication Sciences and Disorders, Western University, London, Ontario, Canada

24. McMaster University, Hamilton, ON, Canada

25. Department of Psychiatry and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

26. Division of Neurology, Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada

27. Sunnybrook Health Sciences Centre, Toronto, ON, Canada

28. Krembil Brain Institute, Toronto Western Hospital, Toronto, ON, Canada

29. Toronto Western Hospital, University Health Network Memory Clinic, Toronto, ON, Canada

30. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada

31. Neuropsychology and Cognitive Health Program, Baycrest Health Sciences, Toronto, ON, Canada

Abstract

Objective Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function. Methods We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD ( N = 111), CVD ( N = 148), PD ( N = 136), FTD ( N = 50) and ALS ( N = 36). We compared the frequency and severity of individual NPS (assessed by the neuropsychiatric inventory questionnaire) across cohorts using generalized estimating equations and analysis of variance. Second, we assessed the relationship of NPS burden with instrumental (iADLs) and basic (ADLs) activities of living across cohorts using multivariate linear regression while adjusting for relevant demographic and clinical covariates. Results Frequency of NPS varied across cohorts (χ2(4) = 34.4, p < .001), with post-hoc tests showing that FTD had the greatest frequency as compared to all other cohorts. The FTD cohort also had the greatest severity of NPS ( H(4) = 34.5, p < .001). Further, there were differences among cohorts in terms of the association between NPS burden and ADLs ( F(4,461) = 3.1, p = 0.02). Post-hoc comparisons suggested that this finding was driven by the FTD group, however, the differences did not remain significant following Bonferroni correction. There were no differences among cohorts in terms of the association between NPS burden and IADLs. Conclusions NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

Link

http://journals.sagepub.com/doi/pdf/10.1177/07067437221147443

Reference34 articles.

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