Tricyclic Medication in Children and the QT Interval: Case Report and Discussion-Reference-Cited by-同舟云学术

Tricyclic Medication in Children and the QT Interval: Case Report and Discussion

Published:1995-08 Issue:6 Volume:40 Page:325-329
ISSN:0706-7437
Container-title:The Canadian Journal of Psychiatry
language:en
Short-container-title:Can J Psychiatry

Author:

Harvey R. Alderton¹

Affiliation:

1. Division of Child Psychiatry, University of Toronto, Toronto, Ontario and Staff Psychiatrist, The Hospital for Sick Children, Toronto, Ontario.

Abstract

Objective To identify the necessity for close monitoring of the QT interval in children and adolescents treated with tricyclics. Method Guidelines for permissible ECG changes are reviewed and a case report of a 12-year-old girl with idiopathic long QT syndrome, no history of cardiac disorder, a questionable family history, and normal physical examination and baseline ECG is presented. Results Marked increase in QT corrected for heart rate (QTc) occurred on low-dose tricyclic. Possible factors in deaths on desipramine are reviewed. Conclusion It is recommended that children and adolescents on tricyclics receive an ECG at baseline and after each dose increase. Recommendations are made regarding ECG parameters and indications for cardiac consultation.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

Link

http://journals.sagepub.com/doi/pdf/10.1177/070674379504000608

Reference30 articles.

1. Imipramine side effects in children

2. Heterocyclic Antidepressants in Children and Adolescents

3. Tricyclic Antidepressants: A Risk for 6–9 Year Olds?

4. Sudden Death and Tricyclic Antidepressants: Clinical Considerations for Children

5. Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary

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