Omega-3 Fatty Acid Supplementation in Adolescents with Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double—Blind, Randomized Controlled Trial-Reference-Cited by-同舟云学术

Omega-3 Fatty Acid Supplementation in Adolescents with Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double—Blind, Randomized Controlled Trial

Published:2013-07 Issue:7 Volume:58 Page:402-408
ISSN:0706-7437
Container-title:The Canadian Journal of Psychiatry
language:en
Short-container-title:Can J Psychiatry

Author:

Amminger G Paul¹,Chanen Andrew M²,Ohmann Susanne³,Klier Claudia M⁴,Mossaheb Nilufar⁵,Bechdolf Andreas⁶,Nelson Barnaby⁷,Thompson Andrew⁸,McGorry Patrick D⁹,Yung Alison R¹⁰,Schäfer Miriam R¹¹

Affiliation:

1. Professor, Psychiatrist, and Child and Adolescent Psychiatrist, Department of Child and Adolescent Psychiatry, Medical university of Vienna, Vienna, Austria; Senior Research Fellow, orygen Youth Health Research Centre, Centre for Youth Mental Health, The university of Melbourne, Melbourne, Australia

2. Senior Research Fellow, orygen Youth Health Research Centre, Centre for Youth Mental Health, The university of Melbourne, Melbourne, Australia; Director of Clinical Services and Psychiatrist, orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia

3. Clinical Psychologist and Psychotherapist, Department of Child and Adolescent Psychiatry, Medical university of Vienna, Vienna, Austria

4. Associate Professor, Psychiatrist, and Child and Adolescent Psychiatrist, Department of Pediatrics and Adolescent Medicine, Medical university of Vienna, Vienna, Austria

5. Psychiatrist and Child and Adolescent Psychiatrist, Department of Psychiatry and Psychotherapy, Medical university of Vienna, Vienna, Austria

6. Professor and Psychiatrist, Department of Psychiatry and Psychotherapy, university of Cologne, Cologne, Germany

7. Senior Research Fellow, orygen Youth Health Research Centre, Centre for Youth Mental Health, The university of Melbourne, Melbourne, Australia; Clinical Psychologist, orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia

8. Senior Research Fellow, orygen Youth Health Research Centre, Centre for Youth Mental Health, The university of Melbourne, Melbourne, Australia; Psychiatrist, orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia

9. Professor and Executive Director, orygen Youth Health Research Centre, Centre for Youth Mental Health, The university of Melbourne, Melbourne, Australia; Psychiatrist, orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia

10. Professor and Psychiatrist, orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia

11. Psychiatrist, Child and Adolescent Psychiatrist, and Study Coordinator, Department of Child and Adolescent Psychiatry, Medical university of Vienna, Vienna, Austria; Psychiatrist, orygen Youth Health Clinical Program, Northwestern Mental Health, Melbourne, Australia; Research Fellow, orygen Youth Health Research Centre, Centre for Youth Mental Health, The university of Melbourne, Melbourne, Australia

Abstract

Objective: To investigate whether long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) improve functioning and psychiatric symptoms in young people with borderline personality disorder (BPD) who also meet ultra-high risk criteria for psychosis. Methods: We conducted a post hoc subgroup analysis of a double-blind, randomized controlled trial. Fifteen adolescents with BPD (mean age 16.2 years, [SD 2.1]) were randomized to either 1.2 g/day n-3 PUFAs or placebo. The intervention period was 12 weeks. Study measures included the Positive and Negative Syndrome Scale, the Montgomery–Åsberg Depression Rating Scale, and the Global Assessment of Functioning. Side effects were documented with the Udvalg for Kliniske Undersøgelser. Fatty acids in erythrocytes were analyzed using capillary gas chromatography. Results: At baseline, erythrocyte n-3 PUFA levels correlated positively with psychosocial functioning and negatively with psychopathology. By the end of the intervention, n-3 PUFAs significantly improved functioning and reduced psychiatric symptoms, compared with placebo. Side effects did not differ between the treatment groups. Conclusions: Long-chain n-3 PUFAs should be further explored as a viable treatment strategy with minimal associated risk in young people with BPD.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health

Link

http://journals.sagepub.com/doi/pdf/10.1177/070674371305800705

Reference41 articles.

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