Folic Acid and Diabetic Foot Ulcers

Author:

Pyrgioti Elisavet E.1,Karakousis Nikolaos D.2ORCID,Georgakopoulos Petros N.3,Karagiannakis Dimitrios S.4,Papanas Nikolaos2ORCID

Affiliation:

1. Pharmacist, Private Practice, Athens, Greece

2. Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece

3. Internal Medicine Department, Primary Healthcare, Amarousion, Attica, Greece

4. Academic Department of Gastroenterology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, Athens, Greece

Abstract

Diabetic foot ulcers (DFUs) remain a major cause of morbidity. This narrative mini-review aimed to investigate the potential role of folic acid (FA) in DFUs. Individuals with DFUs exhibit lower levels of FA and lower daily intake, compared to those without DFUs. There is preliminary evidence that FA administration may contribute to improved DFUs healing. In this context, regular evaluation of dietary FA intake may prove important towards reduction or even prevention of DFUs. However, data are still limited and further research is required to enable definitive conclusions and any recommendations.

Publisher

SAGE Publications

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