Amantadine-Induced Livedo Racemosa

Author:

Criado Paulo Ricardo1,Alavi Afsaneh2,Valente Neusa Yuriko Sakai1,Sotto Mirian Nacagami1

Affiliation:

1. São Paulo University, São Paulo, Brazil

2. University of Toronto, Toronto, Ontario, Canada

Abstract

Although livedo reticularis is a known adverse effect of amantadine, only limited studies have addressed this association. Livedo racemosa in contrast to livedo reticularis is characterized by a striking violaceous netlike pattern of the skin similar to livedo reticularis with a different histopathology and morphology (irregular, broken circular segments). In this case report, we present 2 cases of livedo racemosa and edema of lower extremities following amantadine treatment. The cutaneous biopsies in both cases showed intraluminal thrombi in subcutaneous blood vessels without evidence of vasculitis, which is consistent with livedo racemosa.

Publisher

SAGE Publications

Subject

General Medicine,Surgery

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Amantadine-induced livedo racemosa;BMJ Case Reports;2024-01

2. Extended amantadine-induced livedo reticularis;Revue Neurologique;2021-12

3. Livedo Racemosa: Clinical, Laboratory, and Histopathological Findings in 33 Patients;The International Journal of Lower Extremity Wounds;2020-01-29

4. Drugs That Affect Autonomic Functions or the Extrapyramidal System;Side Effects of Drugs Annual;2017

5. Amantadine;Reactions Weekly;2016-05

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