A Systematic Review and Meta-Analysis of Nutritional Supplementation in Chronic Lower Extremity Wounds

Author:

Ye Junna12,Mani Raj234

Affiliation:

1. Ruijin Hospital, Shanghai, China

2. Shanghai Jiao Tong University, Shanghai, China

3. University of Southampton, Southampton, UK

4. Chiang Mai University, Chiang Mai, Thailand

Abstract

A systematic review and meta-analyses of nutritional supplementation to treat chronic lower extremity wounds was done in order to test the premise that impaired nutrition is implicated in healing. The databases of Ovid MEDLINE, Ovid EMBASE, Cochrane Library, and EBSCO CINAHL (1972-October 2014) were searched systematically. Only randomized controlled trials in adults with chronic lower extremity wounds were included. Both topical and systemic routes of supplementing nutrition were considered. The primary outcome was wound healing. Study characteristics, outcomes, and risk of bias were extracted by trained researchers and confirmed by the principal investigator. Twenty-three of 278 (8.3%) retrieved articles met the inclusion criteria and were selected. Most of the studies were of unclear or low risk. Overall, nutritional supplementation was favorable (risk ratio [RR] = 1.44, 95% confidence interval [CI] = 1.25-1.66). The systemic route was marginally better than the topical one (RR = 1.51, 95% CI = 1.36-1.67; RR = 1.14, 95% CI = 0.96-1.36, respectively). For venous ulcers, the data showed nutritional supplementation to be significantly beneficial compared to placebo (RR = 1.44, 95% CI = 1.31-1.59). Similar data were found for diabetic foot and sickle cell ulcers (RR = 1.17, 95% CI = 0.93-1.47; RR = 1.56, 95% CI = 0.94-2.60, respectively). These data permit the inferences that nutritional supplementation in the populations studied showed significant benefits in the healing of venous ulcers and tendency (nonsignificant trends) in the healing of diabetic and sickle cell ulcers.

Publisher

SAGE Publications

Subject

General Medicine,Surgery

Cited by 21 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Prediction Interval in Meta-Analyses;The International Journal of Lower Extremity Wounds;2023-08-07

2. Magnesium and Diabetic Foot Ulcers: A Mini Review;The International Journal of Lower Extremity Wounds;2023-05-25

3. A Simple Guide to Systematic Reviews and Meta-Analyses;The International Journal of Lower Extremity Wounds;2023-05-01

4. The Role of Nutrients and Diet Characteristics in the Management of Diabetic Foot Ulcers: A Systematic Review;The International Journal of Lower Extremity Wounds;2023-02-03

5. Nutritional supplementation on wound healing in diabetic foot: What is known and what is new?;World Journal of Diabetes;2022-11-15

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