Genetic, Clinical, and Pathologic Backgrounds of Children With X-Linked Alport Syndrome in China: A Monocenter Study

Author:

Juan-Juan Ding1ORCID,Jia Wang1,Li-Li Liu1,Si Wang1,Xiao-Wen Wang1,Jiang-Wei Luan1,Li-Qin Ke1,Jie Sun1,Pei-Wei Zhao1

Affiliation:

1. Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China

Abstract

Background. Characteristics of X-linked Alport syndrome (XLAS) in a cohort of Chinese children. Methods. This work is a retrospective study covering the clinical information, pathological data, and gene sequencing results of 32 cases with XLAS from 2011 to 2022. Results. Among these 32 patients, the youngest age of onset was 3 months. Renal biopsy was performed on 29 children. The lamellated glomerular basement membrane was observed in 19 children using electron microscopy (65.5%). Of the 26 samples tested, 73.1% were found to be negative for collagen-a5 under immunohistochemical staining, showing clinical significance. Next-generation sequencing (NGS) detected 27 pathogenic gene mutations. A total of 15.4% of patients carried de novo mutations. Conclusions. The boys with XLAS showed more typical pathological performance than the girls. Patients with severe mutation were more likely to have proteinuria and hearing impairment. Renal pathology combined with NSG is an important means of diagnosis of AS.

Publisher

SAGE Publications

Subject

Pediatrics,Pediatrics, Perinatology and Child Health

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