Association between Polygenic Risk Scores for ADHD and Asthma: A Birth Cohort Investigation-Reference-Cited by-同舟云学术

Association between Polygenic Risk Scores for ADHD and Asthma: A Birth Cohort Investigation

Published:2021-06-02 Issue:5 Volume:26 Page:685-695
ISSN:1087-0547
Container-title:Journal of Attention Disorders
language:en
Short-container-title:J Atten Disord

Author:

Leffa Douglas Teixeira¹^ORCID,Horta Bernardo²,Barros Fernando C.²,Menezes Ana M. B.²,Martins-Silva Thais²,Hutz Mara Helena³,Bau Claiton Henrique Dotto¹³,Grevet Eugenio Horacio¹,Rohde Luis Augusto¹⁴,Tovo-Rodrigues Luciana²

Affiliation:

1. Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

2. Universidade Federal de Pelotas, Pelotas, Brazil

3. Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

4. National Institute of Developmental Psychiatry, Brazil

Abstract

Objective: Shared genetic mechanisms have been hypothesized to explain the comorbidity between ADHD and asthma. To evaluate their genetic overlap, we relied on data from the 1982 Pelotas birth cohort to test the association between polygenic risk scores (PRSs) for ADHD (ADHD-PRSs) and asthma, and PRSs for asthma (asthma-PRSs) and ADHD. Method: We analyzed data collected at birth, 2, 22, and 30 years from 3,574 individuals. Results: Subjects with ADHD had increased risk of having asthma (OR 1.92, 95% CI 1.01–3.66). The association was stronger for females. Our results showed no evidence of association between ADHD-PRSs and asthma or asthma-PRSs and ADHD. However, an exploratory analysis suggested that adult ADHD might be genetically associated with asthma. Conclusion: Our results do not support a shared genetic background between both conditions. Findings should be viewed in light of important limitations, particularly the sample size and the self-reported asthma diagnosis. Studies in larger datasets are required to better explore the genetic overlap between adult ADHD and asthma.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

Link

http://journals.sagepub.com/doi/pdf/10.1177/10870547211020111

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