Anterior Cingulate Volumetric Alterations in Treatment-Naïve Adults With ADHD

Author:

Makris Nikos1,Seidman Larry J.2,Valera Eve M.3,Biederman Joseph3,Monuteaux Michael C.3,Kennedy David N.3,Caviness Verne S.3,Bush George3,Crum Katherine4,Brown Ariel B.5,Faraone Stephen V.6

Affiliation:

1. Massachusetts General Hospital and Harvard Medical School Boston University School of Medicine,

2. Massachusetts General Hospital, Boston Massachusetts General Hospital and Harvard Medical School

3. Massachusetts General Hospital and Harvard Medical School

4. Boston University

5. Boston University School of Medicine Massachusetts General Hospital and Harvard Medical School

6. SUNY Upstate Medical University

Abstract

Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls ( n = 22), treated ( n = 13) and treatment-naïve adults with ADHD ( n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413)

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

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