Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task-Reference-Cited by-全球学者库

Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task

Published:2023-06-21 Issue:13 Volume:27 Page:1448-1459
ISSN:1087-0547
Container-title:Journal of Attention Disorders
language:en
Short-container-title:J Atten Disord

Author:

Husain Syeda Fabeha¹,Chiang Soon Kiat¹,Vasu Aveline Ajalan¹,Goh Claire P.¹,McIntyre Roger S.²³⁴,Tang Tong Boon⁵,Tran Bach X.⁶⁷,Dang Trang H.T.⁸,Nguyen Tham T.⁹¹⁰,Ho Roger C.¹^ORCID,Ho Cyrus S.¹

Affiliation:

1. National University of Singapore, Singapore

2. University Health Network, Toronto, ON, Canada

3. University of Toronto, ON, Canada

4. Brain and Cognition Discovery Foundation, Toronto, ON, Canada

5. University Teknologi PETRONAS, Seri Iskandar, Perak Darul Ridzuan, Malaysia

6. Hanoi Medical University, Dong Da, Vietnam

7. Johns Hopkins University, Baltimore, MD, USA

8. Institute of Health Economics and Technology, Hanoi, Vietnam

9. Duy Tan University, Da Nang, Vietnam

10. Nguyen Tat Thanh University, Ho Chi Minh, Vietnam

Abstract

Objective: Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC). Method: 75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified. Results: Prefrontal cortex hemodynamic response was lower in patients than HCs (p ≤ ≤.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p > .05). fNIRS measurements were not associated with any clinical variables (p > .05). 75.8% patients and 76% HCs were correctly classified using hemodynamic response. Conclusion: fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies.

Funder

national university of singapore

ministry of higher education, malaysia

National University of Singapore, Department of Psychological Medicine

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

Link

http://journals.sagepub.com/doi/pdf/10.1177/10870547231180111

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