Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1-Reference-Cited by-同舟云学术

Cognition, ADHD Symptoms, and Functional Impairment in Children and Adolescents With Neurofibromatosis Type 1

Published:2019-12-14 Issue:8 Volume:25 Page:1177-1186
ISSN:1087-0547
Container-title:Journal of Attention Disorders
language:en
Short-container-title:J Atten Disord

Author:

Payne Jonathan M.¹²^ORCID,Haebich Kristina M.¹,MacKenzie Rachel³,Walsh Karin S.⁴,Hearps Stephen J. C.¹,Coghill David¹²,Barton Belinda⁵⁶,Pride Natalie A.⁵⁶,Ullrich Nicole J.⁷,Tonsgard James H.⁸,Viskochil David⁹,Schorry Elizabeth K.¹⁰,Klesse Laura¹¹,Fisher Michael J.¹²,Gutmann David H.¹³,Rosser Tena¹⁴,Packer Roger J.⁴,Korf Bruce¹⁵,Acosta Maria T.⁴,Bellgrove Mark A.¹⁶,North Kathryn N.¹²

Affiliation:

1. Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Victoria, Australia

2. University of Melbourne, Parkville, Victoria, Australia

3. La Trobe University, Bundoora, Victoria, Australia

4. Children’s National Health System, Washington, DC, USA

5. The Children’s Hospital at Westmead, New South Wales, Australia

6. The University of Sydney, New South Wales, Australia

7. Boston Children’s Hospital, MA, USA

8. The University of Chicago Medicine Comer Children’s Hospital, IL, USA

9. The University of Utah, Salt Lake City, USA

10. Cincinnati Children’s Hospital Medical Center, OH, USA

11. University of Texas Southwestern Medical Center, Dallas, USA

12. Children’s Hospital of Philadelphia, PA, USA

13. Washington University School of Medicine, St Louis, MO, USA

14. Children’s Hospital Los Angeles, CA, USA

15. The University of Alabama at Birmingham, USA

16. Monash University, Clayton, Victoria, Australia

Abstract

Objective: We examined the contribution of attention and executive cognitive processes to ADHD symptomatology in NF1, as well as the relationships between cognition and ADHD symptoms with functional outcomes. Methods: The study sample consisted of 141 children and adolescents with NF1. Children were administered neuropsychological tests that assessed attention and executive function, from which latent cognitive variables were derived. ADHD symptomatology, adaptive skills, and quality of life (QoL) were assessed using parent-rated questionnaires. Path analyses were conducted to test relationships among cognitive functioning, ADHD symptomatology, and functional outcomes. Results: Significant deficits were observed on all outcome variables. Cognitive variables did not predict ADHD symptomatology. Neither did they predict functional outcomes. However, elevated ADHD symptomatology significantly predicted functional outcomes. Conclusion: Irrespective of cognitive deficits, elevated ADHD symptoms in children with NF1 negatively impact daily functioning and emphasize the importance of interventions aimed at minimizing ADHD symptoms in NF1.

Funder

US Department of Defense Neurofibromatosis Research Program

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

Link

http://journals.sagepub.com/doi/pdf/10.1177/1087054719894384

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