Relationship Between Treatment Duration and Efficacy of Pharmacological Treatment for ADHD: A Meta-Analysis and Meta-Regression of 87 Randomized Controlled Clinical Trials

Author:

Castells Xavier1ORCID,Ramon Maria1,Cunill Ruth23,Olivé Clàudia1,Serrano Domènec14

Affiliation:

1. University of Girona, Spain

2. Parc Sanitari Sant Joan de Déu, Barcelona, Spain

3. Fundació Sant Joan de Déu, Barcelona, Spain

4. Institut d’Assistència Sanitària, Girona, Spain

Abstract

Objective: To determine the relationship between treatment duration and the efficacy of pharmacological treatment for reducing ADHD symptoms. Method: We conducted a systematic review of randomized, double-blind, placebo-controlled clinical trials investigating the efficacy of pharmacological interventions in patients with ADHD. The last bibliographic search was performed in April 15, 2019. The effect of treatment duration on efficacy was studied using meta-regression. Results: A total of 87 studies lasting from 3 to 28 weeks were included. Pharmacological treatment improved ADHD symptom severity by −7.35 points. Treatment duration did not moderate the efficacy of pharmacological treatment. Consistent results were found for psychostimulant drugs, methylphenidate, amphetamine derivatives, atomoxetine, and α2-agonists. A negative correlation was found between baseline ADHD severity efficacy (Coefficient = −.250, p = .013). Conclusion: The efficacy of pharmacological treatment for ADHD remains stable over time. A greater efficacy in more severe patients is suggested.

Funder

Universitat de Girona

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

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