Daily Symptom Profiles of Children With ADHD Treated With Modified-Release Methylphenidate

Author:

Hautmann Christopher1,Rothenberger Aribert2,Döpfner Manfred1

Affiliation:

1. University of Cologne, Germany

2. University of Göttingen, Germany

Abstract

Objective: The aim was to identify subgroups of patients with ADHD with different daily symptom profiles and to characterize their response to modified-release methylphenidate (MR MPH) treatment, using data from the observational trial OBSEER. Method: OBSEER included patients aged 6 to 17 years receiving MR MPH under routine care. To detect subgroups, a latent class cluster analysis was applied. Sex, age, MR MPH dose, and emotional symptoms were considered predictors of response. Results: The analysis included 637 patients (81.3% male), with a mean age (standard deviation) of 10.1 (2.5) years. A two-class solution best fit the data, identifying a high-severity group (49.8%) with pronounced symptom reduction, and a low-severity group (50.2%) with minor changes throughout the day. Younger age, male sex, and higher MPH doses were predictive of the high-severity class. Conclusion: Children with ADHD treated with MR MPH are heterogeneous, and subgroups with differential treatment response can be identified.

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

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