Nocebo Response in Attention Deficit Hyperactivity Disorder: Meta-Analysis and Meta-Regression of 105 Randomized Clinical Trials-Reference-Cited by-同舟云学术

Nocebo Response in Attention Deficit Hyperactivity Disorder: Meta-Analysis and Meta-Regression of 105 Randomized Clinical Trials

Published:2022-02-01 Issue:11 Volume:26 Page:1412-1421
ISSN:1087-0547
Container-title:Journal of Attention Disorders
language:en
Short-container-title:J Atten Disord

Author:

Ramírez-Saco David¹^ORCID,Barcheni Maghie²,Cunill Ruth³⁴,Sáez Marc⁵⁶⁷,Farré Magí²⁸,Castells Xavier⁹^ORCID

Affiliation:

1. School of Medicine, Universitat de Girona, Girona, Spain

2. Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain

3. Parc Sanitari Sant Joan de Déu, Barcelona, Spain

4. Sant Joan de Déu, Institut de Recerca, Sant Boi de Llobregat, Barcelona, Spain

5. Research Group on Statistics, Econometrics and Health (GRECS), Economy Department, Universitat de Girona, Girona, Spain

6. Consortium for Biomedical Research Center of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain

7. Center for Research in Health and Economics (CRES), Economy and Business Department, Universitat Pompeu Fabra, Barcelona, Spain

8. Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

9. TransLab research group, Department of Medical Sciences, Universitat de Girona, Girona, Spain

Abstract

Objective: To determine nocebo response in ADHD, identify covariates modifying nocebo response, and study the relationship between nocebo response and drug safety. Method: Systematic review of randomized, double-blind, placebo-controlled clinical trials (RCT) investigating the efficacy and safety of pharmacological interventions for ADHD patients. The influence of covariates was studied using meta-regression. Results: A total of 105 studies with 8,743 patients in placebo arms were included. Slightly over half (55.5%) of the patients experienced adverse events (AE) while receiving placebo. Nocebo response was associated positively with age, treatment length and method for collecting AEs. Studies with the largest nocebo response showcased the greatest drug response and the best outcome for drug safety. Conclusion: Nocebo response in ADHD RCTs is remarkable, showing a positive relationship with drug response, and a negative relationship with drug safety.

Publisher

SAGE Publications

Subject

Clinical Psychology,Developmental and Educational Psychology

Link

http://journals.sagepub.com/doi/pdf/10.1177/10870547221075845

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