Affiliation:
1. Peking University Sixth Hospital/Institute of Mental Health, Beijing, China
2. National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China
Abstract
Objective: Exploring how abnormal brain function in children with ADHD affects executive function and ultimately leads to behavioral impairment provides a theoretical basis for clinically targeted neurotherapy and cognitive training. Method: Amplitude of low frequency fluctuations (ALFF), regional homogeneity (ReHo), and seed-based FC were analyzed in 53 ADHD and 52 healthy controls. The “brain-cognition-behavior” relationship was further explored using mediation analysis. Results: ADHD showed abnormal local activation in the middle temporal gyrus (MTG), inferior occipital gyrus and inferior frontal gyrus (IFG) and reduced FC between the IFG and the cerebellum. ADHD diagnosis may affect ALFF of MTG and further modulate shift and finally affect inattentive symptoms. It may also affect the total symptoms through the FC of the IFG with the cerebellum. Conclusion: ADHD showed extensive spontaneous activity abnormalities and frontal-cerebellar FC impairments. Localized functional abnormalities in the MTG may affect the shift in EF, resulting in attention deficit behavior.
Funder
the Beijing Municipal Science and Technology Program
the National Natural Science Foundation of China
the National Natural Sciences Foundation of China
the Capital’s Funds for Health Improvement and Research
the Key scientific research projects of capital health development
Subject
Clinical Psychology,Developmental and Educational Psychology