Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study

Author:

Häge Alexander1,Man Kenneth K. C.234,Inglis Sarah K.5,Buitelaar Jan67,Carucci Sara8,Danckaerts Marina9,Dittmann Ralf W.1,Falissard Bruno10,Garas Peter11,Hollis Chris12,Konrad Kerstin1314,Kovshoff Hanna15,Liddle Elizabeth12,McCarthy Suzanne16,Neubert Antje17,Nagy Peter18,Rosenthal Eric19,Sonuga-Barke Edmund J. S.20,Zuddas Alessandro8,Wong Ian C. K.421,Coghill David522,Banaschewski Tobias1ORCID

Affiliation:

1. University of Heidelberg, Mannheim, Germany

2. University College London, UK

3. University College London Hospitals NHS Foundation Trust, UK

4. The University of Hong Kong, Hong Kong

5. University of Dundee, Scotland

6. Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands

7. Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands

8. University of Cagliari and “A.Cao” Paediatric Hospital, Italy

9. University Psychiatric Center KU Leuven, Belgium

10. Université Paris-Saclay, France

11. Semmelweis University, Budapest, Hungary

12. University of Nottingham, UK

13. University Hospital RWTH Aachen, Germany

14. RWTH Aachen and Research Centre Jülich, Germany

15. University of Southampton, UK

16. University College Cork, Ireland

17. Universitätsklinikum Erlangen, Germany

18. Vadaskert Child and Adolescent Psychiatric Hospital and Bethesda Children’s Hospital, Budapest, Hungary

19. Evelina London Children’s Hospital, UK

20. King’s College London, UK

21. Aston University, Birmingham, UK

22. University of Melbourne, Australia

Abstract

Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited. Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study. Participants were recruited into three groups: ADHD patients intending to start MPH-treatment (MPH-group), those not intending to use ADHD-medication (no-MPH-group), and a non-ADHD control-group. Sleep problems were assessed with the Children’s-Sleep-Habits-Questionnaire (CSHQ). Results: 1,410 participants were enrolled. Baseline mean CSHQ-total-sleep-scores could be considered clinically significant for the MPH-group and the no-MPH-group, but not for controls. The only group to show a significant increase in any aspect of sleep from baseline to 24-months was the control-group. Comparing the MPH- to the no-MPH-group no differences in total-sleep-score changes were found. Conclusion: Our findings support that sleep-problems are common in ADHD, but don’t suggest significant negative long-term effects of MPH on sleep.

Funder

European Union’s Seventh Framework Programme for research, technological development and demonstration

Publisher

SAGE Publications

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