The Interplay Between Blood Inflammatory Markers, Symptom Domains, and Severity of ADHD Disorder in Children

Abstract

Objective: ADHD has a multi-factorial etiology among which the inflammatory theory presupposition. We aimed to explore the interplay between blood inflammatory markers; neutrophil lymphocyte ratios (NLR), platelet\lymphocyte ratio (PLR), mean platelet volume (MPV), symptom domains, and severity of ADHD. Method: A total of 50 children with ADHD and 50 healthy controls were recruited. Children were assessed using the mini-international neuropsychiatric interview for children and adolescents (MINI-KID), the Wechsler intelligence scale for children, the Conners’ parent rating scale. Then, NLR, PLR, and MPV were measured. Results: There was a statistically significant difference between children with ADHD and the control group with regard to all blood inflammatory markers (except platelet count). The subtypes and severity of ADHD had no significant relation with NLR, PLR, and MPV. Conclusion: blood inflammatory markers are significantly high in children with ADHD but could not predict specific symptom domains or severity.