Retroperitoneal mixed neuroendocrine non-neuroendocrine neoplasm: A case report and review of literature

Author:

Ashindoitiang John Adi1ORCID,Nwagbara Victor Ikechukwu Canice1,Ipeh Theophilus Ugbem2,Chukwu Ben3,Obanife Henry Olaleye1,Eyong Alfred Ottoh3ORCID,Asuquo Maurice Efana1

Affiliation:

1. Department of Surgery, University of Calabar/University of Calabar Teaching Hospital, Calabar

2. Department of Pathology, University of Calabar/University of Calabar Teaching Hospital, Calabar

3. Department of Surgery, University of Calabar Teaching Hospital, Calabar

Abstract

The existence of both neuroendocrine and non-neuroendocrine histology in variable proportion in a lesion has been described by the World Health Organisation (WHO) as mixed neuroendocrine and non-neuroendocrine neoplasm (MiNEN). The pathogenesis of this tumour remains controversial but molecular studies point towards a common monoclonal origin. Tumours are classified as functioning and nonfunctioning based on substances secreted. The nonfunctioning tumours may be discovered due to its local effect. Presented is a 66-year-old male with an intra-abdominal mass, underwent laparotomy and excision biopsy with transient right lower limb lymphoedema. Histology confirmed retroperitoneal MiNEN with no evidence of tumour recurrence 12 months following surgery. MiNENs should be considered as a differential diagnosis in patients with intra-abdominal mass. Surgical resection is recommended as this may offer the best treatment option.

Publisher

SAGE Publications

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