The Genetics of Success

Author:

Belsky Daniel W.12,Moffitt Terrie E.3456,Corcoran David L.5,Domingue Benjamin7,Harrington HonaLee3,Hogan Sean8,Houts Renate3,Ramrakha Sandhya8,Sugden Karen3,Williams Benjamin S.3,Poulton Richie8,Caspi Avshalom3456

Affiliation:

1. Department of Medicine, Duke University School of Medicine

2. Social Science Research Institute, Duke University

3. Department of Psychology & Neuroscience, Duke University

4. Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine

5. Center for Genomic and Computational Biology, Duke University

6. MRC Social, Genetic & Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

7. Graduate School of Education, Stanford University

8. Dunedin Multidisciplinary Health & Development Research Unit, Department of Psychology, University of Otago

Abstract

A previous genome-wide association study (GWAS) of more than 100,000 individuals identified molecular-genetic predictors of educational attainment. We undertook in-depth life-course investigation of the polygenic score derived from this GWAS using the four-decade Dunedin Study ( N = 918). There were five main findings. First, polygenic scores predicted adult economic outcomes even after accounting for educational attainments. Second, genes and environments were correlated: Children with higher polygenic scores were born into better-off homes. Third, children’s polygenic scores predicted their adult outcomes even when analyses accounted for their social-class origins; social-mobility analysis showed that children with higher polygenic scores were more upwardly mobile than children with lower scores. Fourth, polygenic scores predicted behavior across the life course, from early acquisition of speech and reading skills through geographic mobility and mate choice and on to financial planning for retirement. Fifth, polygenic-score associations were mediated by psychological characteristics, including intelligence, self-control, and interpersonal skill. Effect sizes were small. Factors connecting DNA sequence with life outcomes may provide targets for interventions to promote population-wide positive development.

Publisher

SAGE Publications

Subject

General Psychology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3