Intelligence Polygenic Score Is More Predictive of Crystallized Measures: Evidence From the Adolescent Brain Cognitive Development (ABCD) Study-Reference-Cited by-同舟云学术

Intelligence Polygenic Score Is More Predictive of Crystallized Measures: Evidence From the Adolescent Brain Cognitive Development (ABCD) Study

Published:2023-05-05 Issue:6 Volume:34 Page:714-725
ISSN:0956-7976
Container-title:Psychological Science
language:en
Short-container-title:Psychol Sci

Author:

Loughnan Robert J.¹²,Palmer Clare E.³,Thompson Wesley K.⁴,Dale Anders M.¹⁵⁶⁷,Jernigan Terry L.¹³⁶⁷,Chieh Fan Chun⁴⁶

Affiliation:

1. Department of Cognitive Science, University of California San Diego

2. Population Neuroscience and Genetics, University of California San Diego

3. Center for Human Development, University of California San Diego

4. Center for Population Neuroscience and Genetics, Laureate Institute for Brain Research

5. Center for Multimodal Imaging and Genetics, University of California San Diego School of Medicine

6. Department of Radiology, University of California San Diego School of Medicine

7. Department of Neuroscience, University of California San Diego School of Medicine

Abstract

Findings in adults have shown that crystallized measures of intelligence, which are more culturally sensitive than fluid intelligence measures, have greater heritability; however, these results have not been found in children. The present study used data from 8,518 participants between 9 and 11 years old from the Adolescent Brain Cognitive Development (ABCD) Study. We found that polygenic predictors of intelligence test performance (based on genome-wide association meta-analyses of data from 269,867 individuals) and of educational attainment (based on data from 1.1 million individuals) predicted neurocognitive performance. We found that crystallized measures were more strongly associated with both polygenic predictors than were fluid measures. This mirrored heritability differences reported previously in adults and suggests similar associations in children. This may be consistent with a prominent role of gene–environment correlation in cognitive development measured by crystallized intelligence tests. Environmental and experiential mediators may represent malleable targets for improving cognitive outcomes.

Funder

kavli institute for brain and mind, university of california, san diego

National Institute of Mental Health

Publisher

SAGE Publications

Subject

General Psychology

Link

http://journals.sagepub.com/doi/pdf/10.1177/09567976231160702

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