Inhibition of the Binding of HIV rgp120 to CD4 by Dyes-Reference-Cited by-同舟云学术

Inhibition of the Binding of HIV rgp120 to CD4 by Dyes

Published:1992-06 Issue:3 Volume:3 Page:147-151
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Weaver J. L.¹,Pine P. Scott¹,Anand R.²,Bell S.³,Aszalos A.¹

Affiliation:

1. Division of Research and Testing, CDER/FDA, Washington, DC, USA

2. Laboratory of Retrovirology, CBER/FDA, Bethesda, MD, USA

3. Division of Colors and Cosmetics, CFSAN/FDA, Washington, DC, USA

Abstract

We have found that several dye compounds have the ability to inhibit the binding of HIV rgpl 20 to the Leu3a epitope of CD4 on PBL. One of these compounds, selected for further testing as the best candidate, can inhibit the growth of HIV In vitro. The tested dyes have varying degrees of specificity and efficacy in inhibiting the binding of rgpl 20. These results may point towards compounds that can be useful therapeutics against HIV.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029200300303

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