Pyridazino[3,4-b][1,5]Benzoxazepin-5(6H)-ones: Synthesis and Biological Evaluation-Reference-Cited by-同舟云学术

Pyridazino[3,4-b][1,5]Benzoxazepin-5(6H)-ones: Synthesis and Biological Evaluation

Published:1996-12 Issue:6 Volume:7 Page:300-312
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Barth B.¹,Dierich M.²,Heinisch G.¹,Jenny V.¹,Matuszczak B.¹,Mereiter K.³,Planer R.¹,Schöpf I.¹,Stoiber H.²,Traugott T.¹,Aufschnaiter P. v.¹

Affiliation:

1. Institute of Pharmaceutical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria

2. Institute of Hygiene/Ludwig-Boltzmann Institute for AIDS-Research, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria

3. Institute of Mineralogy, Crystallography and Structural Chemistry, Technical University of Vienna, Getreidemarkt 9, A-1060 Vienna, Austria

Abstract

Starting from 3,6-dichloro-4-pyridazinecarboxylic acid chloride a series of novel pyridazino[3,4- b][1,5]benzoxazepin-5(6 H)-ones as 1,2-diazine isosters of nonnucleoside reverse transcriptase inhibitors was prepared via N-(2-hydroxyphenyl)-3,6-dichloro-4-pyridazinecarboxamides. The inhibition of HIV-1 reverse transcriptase was evaluated.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029600700603

Reference15 articles.

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2. Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

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