Drug Combination of AZT and ddl: Synergism of Action and Prevention of Appearance of AZT-Resistance-Reference-Cited by-同舟云学术

Drug Combination of AZT and ddl: Synergism of Action and Prevention of Appearance of AZT-Resistance

Published:1994-02 Issue:1 Volume:5 Page:51-55
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Antonelli G.¹,Dianzani F.²,Bellarosa D.²,Turriziani O.²,Riva E.²,Gentile A.³

Affiliation:

1. Department of Biomedicine, Section of Virology, University of Pisa, Pisa, Italy

2. Institute of Virology, University ‘La Sapienza’, Rome, Italy

3. Bristol Myers Squibb, Rome, Italy

Abstract

Both 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxynosine (ddl) strongly inhibit the replication of human immunodeficiency virus type 1 (HIV-1). Here, it is shown that combination of AZT and ddl at concentrations that are readily achievable in vivo synergistically inhibit HIV-1 replication in C8166 cells and peripheral blood mononuclear cells. The synergism is significant even when the effect of AZT and ddl alone was negligible. Our findings show that AZT-resistance is less likely to occur when a combination of AZT and ddl is used. Particularly, generation of AZT-resistant strains by in vitro selection is prevented, or delayed, by the combination of AZT plus ddl. Taken together these observations provide a rationale for combination of AZT and ddl in the therapy of AIDS patients.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029400500108

Reference33 articles.

1. Resistance of HIV-1 to AZT Might Also Involve the Cellular Expression of Multidrug Resistance P-Glycoprotein

2. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

3. Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: Receptor modulation and differentiation induced by phorbol ester

4. Loss of Synergistic Response to Combinations Containing AZT in AZT-Resistant HIV-1

5. New acquisitions in the development of anti-HIV agents

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Combination therapy against human infections caused by viruses;Combination Therapy Against Multidrug Resistance;2020

2. Combinatorial CRISPR-Cas9 and RNA Interference Attack on HIV-1 DNA and RNA Can Lead to Cross-Resistance;Antimicrobial Agents and Chemotherapy;2017-12

3. The basic principles for combination therapy;Combination Therapy of AIDS;2004

4. HIV Resistance to Antagonists of Viral Reverse Transcriptase;HIV and the New Viruses;1999

5. Antiviral activity of meliacine on the replication of a thymidine kinase-deficient mutant of Herpes simplex virus type 1 alone and in combination with acyclovir;International Journal of Antimicrobial Agents;1997-06