Effects of a Specific Inhibitor of HIV Proteinase (Ro 31-8959) on Virus Maturation in a Chronically Infected Promonocytic Cell Line (U1)-Reference-Cited by-同舟云学术

Effects of a Specific Inhibitor of HIV Proteinase (Ro 31-8959) on Virus Maturation in a Chronically Infected Promonocytic Cell Line (U1)

Published:1991-06 Issue:3 Volume:2 Page:181-186
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Craig J. C.¹,Grief C.²,Mills J. S.¹,Hockley D.²,Duncan I. B.¹,Roberts N. A.¹

Affiliation:

1. Roche Products Limited, PO Box 8, Welwyn Garden City, Herts AL7 3AY, UK

2. Department of Electron Microscopy and AIDS Collaborative Centre, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Herts, UK

Abstract

The human immunodeficiency virus (HIV) proteinase inhibitor Ro 31-8959 prevents the maturation of virus in phorbol 12-myristate 13-acetate (PMA)-stimulated U1 cells, a chronically infected promonocytic cell line. Inhibition of both the morphological maturation of virions and the enzymic processing of gag polyprotein (p56) to produce capsid protein p24 was demonstrated at nanomolar concentrations of the compound. Furthermore, prolonged inhibition of the processing of p56 antigen was confirmed in pulse-chase experiments. The conclusion is that Ro 31-8959 can inhibit production of mature virions in a promonocyte cell line which is infected chronically/latently with HIV.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029100200308

Reference31 articles.

1. Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line

2. The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

3. The macrophage in the persistence and pathogenesis of HIV infection

4. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

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