A Study of the Efficacy of the Immunomodulatory Compound 7-thia-8-oxoguanosine in Coronavirus 229E Infections in Human Volunteers-Reference-Cited by-同舟云学术

A Study of the Efficacy of the Immunomodulatory Compound 7-thia-8-oxoguanosine in Coronavirus 229E Infections in Human Volunteers

Published:1991-02 Issue:1 Volume:2 Page:61-64
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Higgins P. G.¹,Barrow G. I.¹,Tyrrell D. A. J.¹,Snell N. J. C.²,Jones K.²,Jolley W. B.³

Affiliation:

1. MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wilts SP2 8BW, U.K.

2. ICN European Medical Affairs Group, Eagle House, Peregrine Business Park, Gomm Road, High Wycombe, Bucks HP13 7DL, U.K.

3. ICN Nucleic Acid Research Institute, ICN Plaza, 3300 Hyland Avenue, Costa Mesa, CA 92626, U.S.A.

Abstract

Intranasal 7-thia-8-oxoguanosine (NARI 10146) compared with placebo had no influence on the course of experimental coronavirus 229E infections in human volunteers. Possible reasons are discussed for the failure to confirm successful rodent experiments in man.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029100200110

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