In vitro Evaluation of the Anti-Picornavirus Activities of New Synthetic Flavonoids-Reference-Cited by-同舟云学术

In vitro Evaluation of the Anti-Picornavirus Activities of New Synthetic Flavonoids

Published:1995-10 Issue:5 Volume:6 Page:298-306
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Desideri N.¹,Conti C.²,Sestili I.¹,Tomao P.²,Stein M. L.¹,Orsi N.²

Affiliation:

1. Department of Pharmaceutical Studies, School of Medicine, University ‘La Sapienza’ of Rome, P. le A. Moro, 5, 00185 Rome, Italy

2. Department of Pharmaceutical Studies, and Institute of Microbiology, School of Medicine, University ‘La Sapienza’ of Rome, P. le A. Moro, 5, 00185 Rome, Italy

Abstract

Substituted oxazolinylflavons and oxazolinylflavanones were synthesized in order to compare their anti-picornavirus activities with those of related natural and synthetic compounds. The antiviral potencies of the new compounds were evaluated against rhino-virus type 1B and poliovirus type 2 by a plaque reduction assay in HeLa cell cultures. Among the substituted flavanones only 6-chloro-4′-oxazolinylflavanone showed activity against both viruses. A comparison of the effects of 3-substituted flavones indicated that the presence of a 3-methoxy group enhances the activity against rhinovirus, while the presence of a 3-hydroxy group enhances the activity against poliovirus.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029500600503

Reference27 articles.

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2. Synthesis and anti-rhinovirus activity of halogen-substituted isoflavenes and isoflavans

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