Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs
Author:
Affiliation:
1. Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA.
Publisher
SAGE Publications
Link
http://journals.sagepub.com/doi/pdf/10.1177/095632029700800610
Reference26 articles.
1. Impaired Ketogenesis in Carnitine Depletion Caused by Short-Term Administration of Pivalic Acid Prodrug
2. 9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys
3. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine
4. Activity of the (R)-Enantiomers of 9-(2-Phosphonylmethoxypropyl)-Adenine and 9-(2-Phosphonylmethoxypropyl)-2,6-diaminopurine against Human Immunodeficiency Virus in Different Human Cell Systems
5. Anti‐Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9‐[2‐(bis‐pivaloyloxymethyl)‐phosphonylmethoxyethyl]adenine) in HIV‐Infected Patients
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