Synthesis and Evaluation of 5-Halo 2′,3′-Didehydro-2′,3′-Dideoxynucleosides and their Blocked Phosphoramidates as Potential Anti-Human Immunodeficiency virus Agents: An Example of ‘Kinase Bypass’-Reference-Cited by-同舟云学术

Synthesis and Evaluation of 5-Halo 2′,3′-Didehydro-2′,3′-Dideoxynucleosides and their Blocked Phosphoramidates as Potential Anti-Human Immunodeficiency virus Agents: An Example of ‘Kinase Bypass’

Published:1997-12 Issue:6 Volume:8 Page:519-527
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Mcguigan C¹,Velázquez S¹,De Clercq E²,Balzarini J²

Affiliation:

1. Welsh School of Pharmacy, University of Wales Cardiff, Redwood Building, King Edward VII Avenue, Cardiff CF1 3XF, UK.

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029700800605

Reference28 articles.

1. New Synthesis of 2',3'-Didehydro-2',3'-dideoxynucleosides.

2. Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

3. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

4. Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

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1. Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells;ChemMedChem;2009-11-02

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3. Phosphoramidate Protides of Carbocyclic 2′,3′‐Dideoxy‐2′,3′‐Didehydro‐7‐Deazaadenosine with Potent Activity Against HIV and HBV;Nucleosides, Nucleotides and Nucleic Acids;2004-01-12

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5. Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles;Drugs of the Future;2000