Failure of Castanospermine to Reduce Spleen or Serum Virus Titres in Rauscher Murine Leukaemia Virus-Infected Mice-Reference-Cited by-同舟云学术

Failure of Castanospermine to Reduce Spleen or Serum Virus Titres in Rauscher Murine Leukaemia Virus-Infected Mice

Published:1991-04 Issue:2 Volume:2 Page:119-121
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Hollingshead M. G.¹,Westbrook L.¹,Toyer B. J.¹,Allen L. B.¹

Affiliation:

1. Southern Research Institute, Virology Division B, 2000 Ninth Avenue South, Birmingham, AI 35255, USA

Abstract

The effects of orally administered castanospermine (CS) and azidothymidine (AZT) on spleen and serum virus titres and on spleen weights of mice inoculated with Rauscher murine leukaemia virus (R MuLV) were evaluated. Virus titres of samples from CS-treated mice did not differ appreciably from saline-treated mice, despite a significant inhibition of splenomegaly. In contrast, AZT treatment resulted in significant inhibition of splenomegaly and a reduction of virus titres.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632029100200208

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1. Optimization of the reverse transcriptase assay for the detection of viral burden in mice infected with Rauscher murine leukemia virus;Journal of Virological Methods;1996-10

2. Sodium Deoxycholate Exerts a Direct Destructive Effect on HIV and Influenza Viruses in vitro and Inhibits Retrovirus-Induced Pathology in An Animal Model;Antiviral Chemistry and Chemotherapy;1994-06

3. Iminosugar glycosylation inhibitors as anti-HIV agents;Perspectives in Drug Discovery and Design;1993-08

4. Chapter 3 Simple Indolizidine Alkaloids;The Alkaloids: Chemistry and Pharmacology;1993

5. Progress in the Development Of Natural Products for Human Immunodeficiency Viruses Infections;Natural Products as Antiviral Agents;1992