Synthesis and Antiviral Activities of 1,2,3-triazole Functionalized Thymidines: 1,3-dipolar Cycloaddition for Efficient Regioselective Diversity Generation-Reference-Cited by-同舟云学术

Synthesis and Antiviral Activities of 1,2,3-triazole Functionalized Thymidines: 1,3-dipolar Cycloaddition for Efficient Regioselective Diversity Generation

Published:2005-12 Issue:6 Volume:16 Page:375-383
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Zhou Longhu¹,Amer Adel¹²,Korn Michael¹,Burda Robert¹,Balzarini Jan³,De Clercq Erik³,Kern Earl R.⁴,Torrence Paul F.¹

Affiliation:

1. Department of Chemistry and Biochemistry, Northern Arizona University, AZ, USA

2. On leave from Department of Chemistry, Faculty of Science, Alexandria University, Egypt

3. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

4. Departments of Pediatrics, University of Alabama School of Medicine, Birmingham, AL, USA

Abstract

Efficient regioselective synthesis of nucleoside conjugates was achieved by cycloaddition reaction of azides and alkynes using sodium ascorbate/CuSO4 system as a catalyst. These 16 novel thymidine analogues were obtained in excellent yields (75–100%), employing mild reaction conditions with a broad scope of structural modification. For the compounds tested, no specific antiviral effects could be witnessed against a broad range of viruses.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632020501600604

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