Inosine Monophosphate Dehydrogenase as a Probe in Antiviral Drug Discovery-Reference-Cited by-同舟云学术

Inosine Monophosphate Dehydrogenase as a Probe in Antiviral Drug Discovery

Published:2007-10 Issue:5 Volume:18 Page:245-258
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

Nair Vasu¹,Shu Qingning¹

Affiliation:

1. The Center for Drug Discovery and Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA. USA

Abstract

Inosine monophosphate (IMP) dehydrogenase (IMPDH) is a significant enzyme in the purine nucleotide biosynthetic pathway. IMPDH is viewed as an important biological target in the quest for drugs in the antiviral therapeutic area. This review article is focused on the chemistry and biology of IMPDH inhibitors and the use of IMPDH inhibition data as a probe in antiviral drug discovery. Examples of both inosine 5′ monophosphate and NAD+site-directed inhibitors are presented. Correlation of antiviral activities with IMPDH inhibition is discussed.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632020701800501

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