Anti-Varicella—Zoster Virus Bicyclic Nucleosides: Replacement of Furo by Pyrro Base Reduces Antiviral Potency-Reference-Cited by-同舟云学术

Anti-Varicella—Zoster Virus Bicyclic Nucleosides: Replacement of Furo by Pyrro Base Reduces Antiviral Potency

Published:2000-10 Issue:5 Volume:11 Page:343-348
ISSN:2040-2066
Container-title:Antiviral Chemistry and Chemotherapy
language:en
Short-container-title:Antivir Chem Chemother

Author:

McGuigan C¹,Pathirana RN¹,Jones G¹,Andrei G²,Snoeck R²,De Clercq E²,Balzarini J²

Affiliation:

1. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B-3000, Belgium

Abstract

We have recently reported the discovery of an entirely new category of potent antiviral agents based on novel deoxynucleoside analogues with unusual fluorescent bicyclic furo base moieties. To probe structure-activity relationships and to seek to optimize the properties of the lead compounds, we prepared pyrro analogues of the furo systems. We herein report the synthesis, characterization and antiviral evaluation of these novel compounds.

Publisher

SAGE Publications

Link

http://journals.sagepub.com/doi/pdf/10.1177/095632020001100505

Reference10 articles.

1. Biochemical aspects of the selective antiherpes activity of nucleoside analogues

2. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

3. Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus

4. Steric fixation of bromovinyluracil: Synthesis of furo[2,3-d]pyrimidine nucleosides

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fluorescence properties of 6-aryl-2′-deoxy-furanouridine and –pyrrolocytidine and their derivatives;Methods and Applications in Fluorescence;2017-12-19

2. Synthesis of 5-hetaryluracil derivatives via 1,3-dipolar cycloaddition reaction;Arkivoc;2016-08-29

3. Bicyclic cytarabine analogues: synthesis and investigation of antitumor properties of novel, 6-aryl- and 6-alkyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one arabinosides;Tetrahedron;2015-11

4. Bioactive fused heterocycles: Nucleoside analogs with an additional ring;European Journal of Medicinal Chemistry;2015-06

5. Synthesis, cytotoxicity and antiviral activity studies of the conjugates of cobalt bis(1,2-dicarbollide)(-I) with 5-ethynyl-2′-deoxyuridine and its cyclic derivatives;Tetrahedron;2014-09